Clobetasol Propionate 0.05%

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Clobetasol Propionate Cream

• Frequently relapsing eczema
• Psoriasis (thickened patches of inflamed, red skin, often covered by silvery scales), excluding widespread plaque psoriasis.
• Lichen planus, (a skin disease that causes itchy, reddish-purple, flat-topped bumps on the wrists, forearms or lower legs).
• Discoid lupus erythematosus (a disease of the skin most often affecting the face, ears and scalp causing scarring and increased sensitivity of the affected skin to sunlight).
• Dermatitis and other skin conditions that have not responded to milder steroid creams or ointments.

Dermovate Cream Clobetasol Propionate

• If you are allergic to clobetasol propionate cream or any of the other ingredients listed in the patient information leaflet
• On a child under 1 year of age
• To treat any of the following skin problems, it could make them worse:
  • Acne
  • Severe flushing of skin on and around the nose
  • Spotty red rash around your mouth
  • Itching around your anus or genitals
  • Infected skin (unless the infection is being treated with an anti-infective medicine at the same time)
  • Itchy skin which is not inflamed
  • Widespread plaque psoriasis, except single lesions.

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0.05 Clobetasol Propionate Cream

• You usually apply a thin layer of 0.05 Clobetasol Propionate Cream once or twice a day. This may be reduced as your skin begins to get better, or stopped when better. Your doctor may prescribe a weaker steroid for you to use instead.
• If you are also using an emollient (moisturiser), allow time for 0.05 Clobetasol Propionate Cream to be absorbed into the skin before applying the emollient.
• This cream is for use on the skin only.
• Do not use for more than 4 weeks without talking to a doctor. If you need treatment for a long time, your doctor may decide you need to use a milder cream or ointment.
• If your skin problem worsens or does not improve within 2 to 4 weeks, talk to your doctor.
• The germs that cause infections like the warm and moist conditions under dressings. If directed to cover the treated area with a dressing, always clean the skin before a fresh dressing is put on to help prevent infection of the skin beneath the dressing.
• If you are applying 0.05 Clobetasol Propionate Cream on someone else make sure you wash your hands after use or wear disposable plastic gloves.

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• Wash your hands.
• Apply a thin layer to the affected area(s) and gently rub into the skin until it has all disappeared. You can measure how much Clobetasol Propionate Cream to use with your fingertip. For children you will need to use less cream but still use an adult finger to measure out the fingertip unit.
• Unless you are meant to apply the cream to your hands as a part of the treatment, wash them again after using the Clobetasol Propionate Cream 0.05.

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Clobetasol Propionate Cream USP 0.05

• You find that your skin problem gets worse, you develop a generalised rash or your skin becomes swollen during treatment. You may be allergic to the cream, have an infection or need other treatment.
• You have psoriasis and get raised bumps with pus under the skin. This can happen during or after the treatment and is known as pustular psoriasis.

• A feeling or burning, pain, irritation or itching where the cream is applied.

• Skin thinning, this may cause stretch marks
• Blood vessels under the surface of the skin may become more noticeable

• Use of Clobetasol Propionate Cream USP 0.05 for a long period of time, or use under an airtight dressing, may cause the following symptoms:
  • Increased weight
  • Moon face, rounding of the face
  • Obesity
  • Skin thinning
  • Skin wrinkling
  • Skin dryness
  • Changes to the colour of your skin
  • Increased body hair
  • Hair loss/lack of hair growth/damaged looking hair

Clobetasol Propionate Dermovate Cream

• Very mild (hydrocortisone)
• Moderate (Betamethasone valerate and clobetasone butyrate)
• Strong (a higher dose of Betamethasone valerate and betamethasone dipropionate)
• Very strong (clobetasol proprionate and diflucortolone valterate)

• Self-care techniques, such as reducing scratching and avoiding triggers.
• Emollients
• Soap alternatives
• Topical corticosteroids that are used to reduce swelling, redness and itching during flare-ups.

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Eczema

Atopic eczema (atopic dermatitis) is the most common form of eczema, a condition that causes the skin to become itchy, dry and cracked.

Atopic eczema is more common in children, often developing before their first birthday. But it may also develop for the first time in adults.

It’s usually a long-term (chronic) condition, although it can improve significantly, or even clear completely, in some children as they get older.

Symptoms of atopic eczema
Atopic eczema causes the skin to become itchy, dry, cracked and sore.

Some people only have small patches of dry skin, but others may experience widespread inflamed skin all over the body.

Inflamed skin can become red on lighter skin, and darker brown, purple or grey on darker skin. This can also be more difficult to see on darker skin.

Although atopic eczema can affect any part of the body, it most often affects the hands, insides of the elbows, backs of the knees and the face and scalp in children.

People with atopic eczema usually have periods when symptoms are less noticeable, as well as periods when symptoms become more severe (flare-ups).

When to seek medical advice
See a GP if you have symptoms of atopic eczema. They’ll usually be able to diagnose atopic eczema by looking at your skin and asking questions, such as:

whether the rash is itchy and where it appears
when the symptoms first began
whether it comes and goes over time
whether there’s a history of atopic eczema in your family
whether you have any other conditions, such as allergies or asthma
whether something in your diet or lifestyle may be contributing to your symptoms
Typically, to be diagnosed with atopic eczema you should have had an itchy skin condition in the last 12 months and 3 or more of the following:

visibly irritated red skin in the creases of your skin – such as the insides of your elbows or behind your knees (or on the cheeks, outsides of elbows, or fronts of the knees in children aged 18 months or under) at the time of examination by a health professional
a history of skin irritation occurring in the same areas mentioned above
generally dry skin in the last 12 months
a history of asthma or hay fever – children under 4 must have an immediate relative, such as a parent, brother or sister, who has 1 of these conditions
the condition started before the age of 2 (this does not apply to children under the age of 4)
Causes of atopic eczema
The exact cause of atopic eczema is unknown, but it’s clear it is not down to one single thing.

Atopic eczema often occurs in people who get allergies. “Atopic” means sensitivity to allergens.

It can run in families, and often develops alongside other conditions, such as asthma and hay fever.

The symptoms of atopic eczema often have certain triggers, such as soaps, detergents, stress and the weather.

Sometimes food allergies can play a part, especially in young children with severe eczema.

You may be asked to keep a food diary to try to determine whether a specific food makes your symptoms worse.

Allergy tests are not usually needed, although they’re sometimes helpful in identifying whether a food allergy may be triggering symptoms.

Treating atopic eczema
Treatment for atopic eczema can help to relieve the symptoms and many cases improve over time.

But there’s currently no cure and severe eczema often has a significant impact on daily life, which may be difficult to cope with physically and mentally.

There’s also an increased risk of skin infections.

Many different treatments can be used to control symptoms and manage eczema, including:

self-care techniques, such as reducing scratching and avoiding triggers
emollients (moisturising treatments) – used on a daily basis for dry skin
topical corticosteroids – used to reduce swelling, redness and itching during flare-ups
Other types of eczema
Eczema is the name for a group of skin conditions that cause dry, irritated skin.

Other types of eczema include:

discoid eczema – a type of eczema that occurs in circular or oval patches on the skin
contact dermatitis – a type of eczema that occurs when the body comes into contact with a particular substance
varicose eczema – a type of eczema that most often affects the lower legs and is caused by problems with the flow of blood through the leg veins
seborrhoeic eczema – a type of eczema where red, scaly patches develop on the sides of the nose, eyebrows, ears and scalp
dyshidrotic eczema (pompholyx) – a type of eczema that causes tiny blisters to erupt across the palms of the hands

Side Effects

Stop using Dermovate and tell your doctor immediately if:
• you find that your skin problem gets worse, you develop a generalised rash or your skin becomes swollen during treatment. You may be allergic to the cream, have an infection or need other treatment.
• you have psoriasis and get raised bumps with pus under the skin. This can happen during or after the treatment and is known as pustular psoriasis.

Further Information

Patient Information Leaflet