Chloroquine 250mg – 20 Tablets

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• People travelling to countries where malaria occurs
• People living in malaria areas who are not immune to malaria

• A high temperature above 38C
• Feeling hot and shivery
• Muscle pains
• Headaches
• Diarrhoea
• Vomiting

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Chloroquine Phosphate Tablets

• You are allergic to chloroquine phosphate or any of the other ingredients in Chloroquine Phosphate Tablets
• You are taking a medicine called amiodarone as Chloroquine Tablets UK may increase the risk of uneven heart beats (cardiac arrhythmias) when it is taken at the same time as amiodarone

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• Take two Chloroquine tablets once a week on the same day each week

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Chloroquine Malaria Tablets

• Praziquantel
• Ciclosporin
• Anti-convulsant medicines
• Digoxin

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Chloroquine Tablet Dosage For Adults

• Ages 1 to 4 years: Take half a tablet once a week (on the same day each week)
• Ages 5 to 8 years: Take one tablet once a week (on the same day each week)
• Ages 9 to 14 years: Take one and a half tablets once a week (on the same day each week)

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• Wear light-coloured, long-sleeved clothing and long trousers when you are outside after sunset
• Use insect repellent creams or sprays on parts of your body not covered by clothing
• Sleep in a properly screened room or under a mosquito net
• Spray to kill any mosquitoes that may have entered rooms in spite of screening

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• Start taking this medicine one week before you enter the malaria area
• You must continue to take it during your stay
• You must keep taking this medicine for 4 weeks after leaving the malaria area

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• Keep this medicine out of the sight and reach of children
• Do not store your medicine above 30C
• Protect the tablets from light and moisture
• Keep the tablets in the container they came in
• Do not take Chloroquine 250mg Tablet after the expiry date stated on the carton. The expiry date refers to the last day of that month

Chloroquine Phosphate Tablets Side Effects

• Allergic reactions including difficulty breathing, swelling of the face, lips, tongue or throat which may cause difficulty in swallowing and an itchy rash
• A severe rash with blisters or peeling of the skin and possibly blisters in the mouth and nose
• Seeing, feeling or hearing things that are not there
• Cardiac muscle disease (cardiomyopathy)
• Abnormal heart rhythm, life-threatening irregular heart rhythm (seen on ECG)

Side Effects

Serious side effects
If you experience any of the following side effects, stop taking Avloclor and get medical help or contact your doctor straight away.
• Allergic reactions including difficulty breathing, swelling of the face, lips, tongue or throat which may cause difficulty in swallowing and an itchy rash (similar to nettle rash or hives)
• A severe rash with blisters or peeling of the skin and possibly blisters in the mouth and nose.
• Seeing, feeling or hearing things that are not there (hallucinations) (rare).
• Cardiac muscle disease (cardiomyopathy) which may be fatal in case of high-dose longterm use. See section 2, warnings and precautions (rare).
• Abnormal heart rhythm, life-threatening irregular heart rhythm (seen on ECG). See section 2, Warnings and precautions (frequency not known).
• Liver problems which may cause yellowing of your skin or the whites of your eyes.

If you are taking Avloclor for a long time, your doctor may suggest that you have blood tests to check how well your liver is working (rare).
• Inflammation of the lungs causing a condition known as diffuse parenchymal lung disease.
If you develop serious breathlessness or worsening of breathlessness seek prompt medical advice.
• Convulsions or fits.
• Some or complete loss of eyesight.
• Changes to the retina of your eye (retinopathy) or to the cornea. This can lead to ‘patchy’
eyesight.
• A rash caused by the medicine associated with an increase in the number of white blood cells (that may show up in blood tests) and symptoms involving the whole body. You may notice some or all of the following symptoms: a skin rash and fever, swelling of the face, tender generalized swollen or enlarged lymph nodes, or other symptoms suggesting involvement of other body organs including the liver, kidney or lung (such as yellowing of the skin or eyes, urinary problems, breathlessness).

• A reduced number of blood cells. This can make you bruise more easily, get serious infections, have sudden bleeding or feel very tired or breathless. If you are taking
Avloclor for a long time, your doctor may suggest that you have blood tests.
Other possible side effects (frequency not known)
When Avloclor is used to prevent or suppress malaria, these are generally not serious. If Avloclor is used for a long time, they can be more serious.

Heart
• Changes in the way your heart works (known as ‘electrocardiographic changes’).
• Low blood pressure. This may make you feel faint or dizzy.

Nervous system

• Headache.
• Feeling dizzy or light-headed.
• Involuntary muscle movements or spasms.

Behaviour
• Insomnia.
• Mood changes or other effects on behaviour. These include feeling depressed, confused or
anxious.

Skin
• Skin rash, including a scaly rash (psoriasis) or itch.
• Peeling skin.
• Discolouration of the skin or mucous membranes (such as the inside of your mouth).
• Being sensitive to sun light which may require medical treatment.
• The appearance of small fluid filled bumps on the skin.

Hair
• Changes in hair colour.
• Hair loss.

Eyes
• Blurred eyesight.
• Problems with your colour vision.
• Difficulty in focussing your eyes.
• Double vision.
If you are taking Avloclor for a long time, your doctor may suggest that you have eye tests.

Ears
• Hearing loss.
• Ringing in the ears (tinnitus).

Stomach and gut
• Stomach upsets, feeling sick (nausea), being sick (vomiting), diarrhoea or stomach cramps.

Other
• Weakening of your muscles (neuromyopathy and myopathy).

Malaria

Malaria is a serious tropical disease spread by mosquitoes. If it isn’t diagnosed and treated promptly, it can be fatal.

A single mosquito bite is all it takes for someone to become infected.

Symptoms of malaria
It’s important to be aware of the symptoms of malaria if you’re travelling to areas where there’s a high risk of the disease. Symptoms include:

– a high temperature (fever)
– sweats and chills
– headaches
– vomiting
– muscle pains
– diarrhoea
Symptoms usually appear between 7 and 18 days after becoming infected, but in some cases the symptoms may not appear for up to a year, or occasionally even longer.

When to seek medical attention

Seek medical help immediately if you develop symptoms of malaria during or after a visit to an area where the disease is found.

Malaria risk areas

Malaria is found in more than 100 countries, mainly in tropical regions of the world, including:

– Large areas of Africa and Asia
– Central and South America
– Haiti and the Dominican Republic
– Parts of the Middle East
– Some Pacific islands

The Fit for Travel website has more information about the risk of malaria in specific countries.

Preventing malaria

Many cases of malaria can be avoided. An easy way to remember is the ABCD approach to prevention:

– Awareness of risk – find out whether you’re at risk of getting malaria before travelling
– Bite prevention – avoid mosquito bites by using insect repellent, covering your arms and legs, and using an insecticide-treated mosquito net
– Check whether you need to take malaria prevention tablets – if you do,make sure you take the right antimalarial tablets at the right dose, and finish the course
– Diagnosis – seek immediate medical advice if you develop malaria symptoms, as long as up to a year after you return from travelling

Further Information

Patient Information Leaflet