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Wegovy pills contain the same active ingredient as Wegovy injections: semaglutide. This means that they work in the same way. Semaglutide is a medicine known as a GLP-1 receptor agonist. This means it takes on the role of GLP-1 in your body, a natural hormone responsible for managing your blood sugar and regulating your appetite. By mimicking this hormone, the Wegovy tablets work by:

reducing appetite and food cravings (food noise)
helping you feel fuller for longer after meals
regulating blood sugar, preventing spikes and food cravings

Is Wegovy the same as Rybelsus?

Both Wegovy tablets and Rybelsus tablets contain semaglutide, meaning they work as GLP-receptor agonists. However, they’re approved to treat different conditions, and have different maximum doses:

Wegovy: approved to treat type 2 diabetes and weight loss in injection form (Wegovy tablets have not yet been approved for use in the UK). Comes in 1.5mg, 4mg, 9mg and 25mg doses.
Rybelsus: approved to treat type 2 diabetes. Comes in 1.5mg, 5mg and 9mg.

What’s the difference between Wegovy tablets and injections?

Here are the biggest differences between Wegovy tablets and injections, based on information provided by the manufacturer:

Doses: Both the tablets and injections start at a lower dose and increase over time. However, the actual doses are different as your body takes in the medicine in different ways. For injections the medicine is absorbed into the bloodstream, while tablets are taken in through the digestive system.
Efficacy: On average, people taking the tablets lose around 14% of their body weight during clinical studies, compared to around 21% with the injections.
Frequency: You take the tablet once a day in the morning. The injection is taken once a week.

Wegovy tablets effectiveness in clinical trials

Wegovy tablets have been shown to be effective in helping lose weight, compared to a placebo. The OASIS 4 trial, carried out in late 2025, looked at the use of oral semaglutide (Wegovy tablets) in adults who were overweight or obese over 71 weeks. Importantly the tablets were only studied over the course of 68 weeks. The average weight lost among participants who were taking Wegovy tablets was 14% of their total body weight. Over 1 in 4 people (28%) taking Wegovy tablets lost over 20% of their body weight over 68 weeks, showing similar numbers to 7.2mg Wegovy injections, which had an average weight loss of 21% over 72 weeks.

Wegovy tablets dosage

The current Wegovy tablet doses available are:

1.5mg
4mg
9mg
25mg

Like with injections, the manufacturer recommends when taking Wegovy tablets you start at a lower dose, so your body can adjust to the medication. You can then slowly increase your dose if your current strength isn’t providing the results you want, and your healthcare professional agrees it’s suitable. If you are looking to move to a higher dose, you’ll usually do so after taking your current dose for at least 30 days. Importantly, as the tablet is absorbed into the body in a different way, the doses are not the same as Wegovy injections.

Wegovy tablets eligibility

As Wegovy tablets are not yet available in the UK, we do not currently know who will be eligible to use them if they get approved. However, it could be possible that the same criteria are used for the tablets as is for the injections, as is the case in the US. This would mean the criteria would be:

a BMI of 30 or more
a BMI of 27 or more (if you have a health condition, like high blood pressure)

Similarly, it might be the case that the list of those the medication is unsuitable for remains the same. This may include people who:

are pregnant, trying to get pregnant, or breastfeeding
have a history of pancreatitis, or inflammation of your pancreas

Wegovy tablets on the NHS

Current NHS requirements for Wegovy injections in the UK may indicate what the eligibility for Wegovy tablets could be in the future. Currently, you may be prescribed Wegovy weight loss injections if diet and exercise have not worked alone, you have a health problem due to your weight and a BMI of either:

35 or more
30 or more if you meet criteria to be treated by a specialise weight management service

However, we don’t know if and when Wegovy tablets will become available on the NHS.

Understanding different weight management treatment options

Wegovy Tablets

Wegovy Injections

Mounjaro Injections

Xenical

Mysimba

Active Ingredient

Semaglutide

Tirzepatide

Orlistat

Naltrexone & Bupropion

Manufacturer

Novo Nordisk

Eli Lilly

Roche

Orexigen

Doses

1.5mg, 4mg, 9mg, 25mg

0.25mg, 0.5mg, 1mg, 1.7mg, 2.4mg, 7.2mg

2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg

120mg

8mg/90mg

Price (£)

TBD

£90–£200

£140–£350

£45–£70

£90–£115

Weight loss during clinical studies

Frequency

1 tablet daily

Once-weekly injection (1 pen = 4 weeks)

3 tablets daily at mealtimes

1–4 tablets daily

Availability

TBD

Private: following consultation.NHS: BMI 30+ with health problems due to weight.

Private: following consultation.NHS: BMI 30+ with 4+ obesity-related health concerns.

Private: following consultation.NHS: BMI 30+ with other weight-related conditions.

Private: following consultation.

Directions of use

The directions for Wegovy tablets (as they’ve been approved in the US) are as follows:

Take one tablet a day. Take first thing in the morning, on an empty stomach, with a small sip of water.
Tablets are swallowed whole. They cannot be split or crushed.
Wegovy tablets should be taken at least 30 minutes before you eat, drink, or take any other medication.

Potential side effects of Wegovy tablets

Like any medication, Wegovy can cause side effects in some, though in clinical trials they were usually mild and manageable. Side effects are most likely to happen when you first start treatment but will usually go away on their own as your body gets used to the medication. Common side effects during clinical trials included:

nausea or vomiting
diarrhoea
constipation
sulphur burps

Warnings

The manufacturer states you should or avoid this medication if:

you are under 18, pregnant or breastfeeding
have a personal or family history of certain types of thyroid cancer
are allergic to semaglutide
have multiple endocrine neoplasia syndrome 2

Storage information

According to information provided by Novo Nordisk (for the Wegovy tablets that are currently approved in the US) to store your medication safely, you should:

keep tablets at room temperature (between 20°C to 25°C)
store in a dry place away from moisture (consider avoiding bathrooms)
keep tablets in their original bottle, with the lid tightly closed
keep out of reach of children

Importantly, there is currently no requirement for these tablets to be refrigerated, unlike the Wegovy weight loss injections.

Frequently asked questions about Wegovy tablets

Are Wegovy tablets cheaper than weight loss injections?

Currently, we do not know what the price of Wegovy tablets will be in the UK, even compared to weight loss injections, as it has not yet been approved by the MHRA.

Will Wegovy tablets be available on the NHS?

If approved in the UK, it’s likely that Wegovy tablets will eventually be available on the NHS. This is because Wegovy injections are already available on the NHS.