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Atovaquone and Proguanil 250mg/100mg (Generic Malarone)

£1.99 £1.89

  • Nine Tablets Plus Number Of Days Holiday Is Required Total
  • Active Ingredients: Atovaquone & Proguanil Hydrochloride
  • Prevent Contraction Of Malaria When Travelling To Tropical Regions
  • Buy With Confidence From UK Registered Pharmacy
  • Includes Free Prescription

These anti-malaria tablets are advised for those travelling to tropical regions in areas such as Africa, South America and Southern Asia.

Take the medication 1 to 2 days prior to entry and up to one week after leaving therefore you will need nine tablets plus the number the number of days holiday.

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Atovaquone And Proguanil 250mg 100mg Single Tablet

Atovaquone And Proguanil 250mg 100mg Single Tablet belongs to a group of medicines called antimalarials. It contains two active ingredients, atovaquone and proguanil hydrochloride.

Atovaquone And Proguanil 250mg 100mg Single Tablet is used to:

  • Prevent malaria
  • Treat malaria

Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium falciparum) into the bloodstream. Atovaquone/Proguanil Hydrochloride prevents malaria by killing this parasite. For people who are already infected with malaria, Atovaquone And Proguanil 250mg 100mg Single Tablet also kills these parasites.

Malaria Overview – NHS Website

Atovaquone 250mg And Proguanil 100mg

What you need to know before you take Atovaquone 250mg And Proguanil 100mg:

Do not take Atovaquone 250mg And Proguanil 100mg

  • If you are allergic to atovaquone, proguanil hydrochloride or any of the other ingredients of this medicine.
  • For preventing malaria, if you have severe kidney disease.

Atovaquone 250mg And Proguanil 100mg is not recommended in children who weigh less than 11 kg. Another strength of Atovaquone/Proguanil Hydrochloride tablet may be available which are more suitable for children who weigh less than 11 kg.

Atovaquone And Proguanil 250mg 100mg

Other medicines and Atovaquone And Proguanil 250mg 100mg

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. Some medicines can affect the way Atovaquone And Proguanil 250mg 100mg works, or Atovaquone And Proguanil 250mg 100mg itself can strengthen or weaken the effectiveness of other medicines taken at the same time.

These include:

  • Metoclopramide, used to treat nausea and vomiting
  • The antibiotics, tetracycline, rifampicin and rifabutin
  • Efavirenz or certain highly active protease-inhibitors used to treat HIV
  • Warfarin and other medicines that stop blood clotting
  • Etoposide used to treat cancer

Atovaquone 250mg Proguanil 100mg

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Atovaquone 250mg Proguanil 100mg should not be used during pregnancy unless your doctor recommends it.

You should not breast-feed while taking Atovaquone 250mg Proguanil 100mg, as the ingredients of Atovaquone 250mg Proguanil 100mg may pass into breast milk and may hard the baby.

Atovaquone 250mg Proguanil Hydrochloride 100mg

To prevent malaria:

The recommended dose for adults and children weighing at least 40 kg is 1 tablet once a day, taken as below. Atovaquone 250mg Proguanil Hydrochloride 100mg is not recommended for preventing malaria in children, or in adults or adolescents who weigh less than 40 kg. There may be different type of tablets available in your country for preventing malaria in children and adults who weigh less than 40 kg.

  • Start taking Atovaquone 250mg Proguanil Hydrochloride 100mg one to two days before travelling to an area which has malaria
  • Continue taking it every day during your stay
  • Continue taking it for another seven days after your return to a malaria-free area

Atovaquone And Proguanil 250mg 100mg Single Tablet Malarone Generic Tablets

To treat Malaria:

The recommended dose of Atovaquone And Proguanil 250mg 100mg Single Tablet Malarone Generic Tablets for adults is four tablets once a day for three days.

For children weighing 11 kg or more the Atovaquone And Proguanil 250mg 100mg Single Tablet Malarone Generic Tablets dose depends on their bodyweight:

  • 11-20kg – one tablet once a day for a three days
  • 21-30 kg – two tablets once a day for three days
  • 31-40 kg – three tablets once a day for three days
  • Over 40 kg – dose as for adults

Proguanil 100mg Atovaquone 250mg

It’s very important that you take the full course of Proguanil 100mg Atovaquone 250mg.

If you forget to take a Proguanil 100mg Atovaquone 250mg dose, do not worry. Just take your next dose as soon as you remember. Then continue your treatment as before.

Do not take a double Proguanil 100mg Atovaquone 250mg dose to make up for a forgotten dose.

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Atovaquone 250mg Proguanil 100mg Combination

Atovaquone 250mg Proguanil 100mg Combination should be stored out of the sight and reach of children.

Atovaquone 250mg Proguanil 100mg Combination should not be used after the expiry date stated on the blister and the carton. The date refers to the last day of the month.

Store in the original package in order to avoid moisture.

Atovaquone 250mg Proguanil 100mg Combination Preparation

Apart from the two active ingredients, Atovaquone 250mg Proguanil 100mg Combination Preparation has other ingredients:

  • The tablet core: Cellulose microcrystalline, Povidone, Crospovidone, Poloxamer 188, Magnesium stearate.
  • Film coat: Titanium dioxide, latose monohydrate, Macrogol 4000, Hypromellose 15cP, Hypromellose 50cP, Hypromellose 3cP, Iron oxide red, Iron oxide black, Iron oxide yellow.

Each tablet contains Atovaquone 250mg Proguanil 100mg Combination Preparation.

Atovaquone 250mg Proguanil 100mg Generic

Atovaquone 250mg Proguanil 100mg Generic are the alternative to Malarone tablets. There are no differences between the two apart from the brand name and pricing.

Because of a license change in recent years, other manufacturers can now distribute and sell their own branded versions of Atovaquone 250mg Proguanil 100mg Generic.

Atovaquone And Proguanil 250mg 100mg Side Effects

Like with all medicine, Atovaquone And Proguanil 250mg 100mg Side Effects can occur but these aren’t experienced by everyone. If you experience any of these Atovaquone And Proguanil 250mg 100mg side effects, especially if any of them are getting progressively worse, immediately stop and speak to your doctor as soon as possible.

Below is a list of Atovaquone And Proguanil 250mg 100mg Side Effects experienced more, or less when people have taken a Malaria treatment. For a full list, please refer to the patient information leaflet.

Very Common Side Effects

  • Headache
  • Feeling sick and being sick
  • Stomach pain
  • Diarrhoea

Common Side Effects

  • Dizziness
  • Sleeping problems
  • Strange dreams
  • Depression
  • Loss of appetite
  • Fever
  • Rash, which may be itchy
  • Cough

Uncommon Side Effects

  • Anxiety
  • Awareness of abnormal beating of the heart
  • Swelling and redness of the mouth
  • Hair loss

Rare Side Effects

  • Seeing or hearing things that aren’t there (hallucinations)
Malaria

Malaria is a serious tropical disease spread by mosquitoes. If it isn’t diagnosed and treated promptly, it can be fatal.

A single mosquito bite is all it takes for someone to become infected.

Symptoms of malaria
It’s important to be aware of the symptoms of malaria if you’re travelling to areas where there’s a high risk of the disease. Symptoms include:

a high temperature (fever)
sweats and chills
headaches
vomiting
muscle pains
diarrhoea
Symptoms usually appear between 7 and 18 days after becoming infected, but in some cases the symptoms may not appear for up to a year, or occasionally even longer.

When to seek medical attention
Seek medical help immediately if you develop symptoms of malaria during or after a visit to an area where the disease is found.

Malaria risk areas
Malaria is found in more than 100 countries, mainly in tropical regions of the world, including:

large areas of Africa and Asia
Central and South America
Haiti and the Dominican Republic
parts of the Middle East
some Pacific islands

The Fit for Travel website has more information about the risk of malaria in specific countries.

Preventing malaria
Many cases of malaria can be avoided. An easy way to remember is the ABCD approach to prevention:

awareness of risk – find out whether you’re at risk of getting malaria before travelling
bite prevention – avoid mosquito bites by using insect repellent, covering your arms and legs, and using an insecticide-treated mosquito net
check whether you need to take malaria prevention tablets – if you do,make sure you take the right antimalarial tablets at the right dose, and finish the course
diagnosis – seek immediate medical advice if you develop malaria symptoms, as long as up to a year after you return from travelling

Side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, but their exact
frequency is unknown.
Severe allergic reactions – signs include:
 rash and itching
 sudden wheezing, tightness of the chest or throat, or difficulty breathing or low blood pressure
 swollen eyelids, face, lips, tongue or other part of the body
Contact a doctor immediately if you get any of these symptoms and stop taking Atovaquone/Proguanil
Hydrochloride.
Severe skin reactions:
 skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area
with a dark ring around the edge) (erythema multiforme)
 severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose,
eyes and genitals (Stevens-Johnson syndrome)
If you notice any of these symptoms contact a doctor urgently.
Most of the other side effects reported have been mild and have not lasted very long.
Very common side effects (may affect more than 1 in 10 people):
 headache
 feeling sick and being sick (nausea and vomiting)
 stomach pain
 diarrhoea
Common side effects (may affect up to 1 in 10 people):
 dizziness
 sleeping problems (insomnia)
 strange dreams
 depression
 loss of appetite
 fever
 rash, which may be itchy
 cough
5
Common side effects which may show up in your blood tests are:
 reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness of
breath
 reduced numbers of white blood cells (neutropenia) which may make you more likely to catch
infections
 low levels of sodium in the blood (hyponatraemia)
 an increase in liver enzymes
Uncommon side effects (may affect up to 1 in 100 people)
 anxiety
 an unusual awareness of abnormal beating of the heart (palpitations)
 swelling and redness of the mouth
 hair loss
Uncommon side effects that may show up in your blood tests:
 An increase in amylase (an enzyme produced in the pancreas)
Rare side effects (may affect up to 1 in 1,000 people):
 seeing or hearing things that are not there (hallucinations)
Not known (frequency cannot be estimated from the available data)
Other side effects have occurred in a small number of people but their exact frequency is unknown.
 inflammation of the liver (hepatitis)
 blockage of the bile ducts (cholestasis)
 increase in heart rate (tachycardia)
 inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots on the
skin but can affect other parts of the body
 fits (seizures)
 panic attacks, crying
 nightmares
 severe mental condition in which the person loses contact with reality and is unable to think and judge
clearly
 mouth ulcers
 blisters
 peeling skin
 increased sensitivity of the skin to sunlight
Other side effects that may show up in your blood tests:
 in people with severe kidney disease, decrease in all types of blood cells (pancytopenia)

Patient Information