Atovaquone and Proguanil 250mg/100mg (Generic Malarone)


  • Nine tablets plus number of days holiday is required total
  • Active Ingredients: Atovaquone And Proguanil Hydrochloride
  • Prevent Contraction Of Malaria When Travelling To Tropical Regions
  • Buy With Confidence From UK Registered Pharmacy
  • Includes Free Prescription

These anti-malaria tablets are advised for those travelling to tropical regions in areas such as Africa, South America and Southern Asia. The two main active ingredients: atovaquone and proguanil hydrochloride, both act differently to provide effective protection from Malaria by killing the parasite directly.

Take the  medication 1 to 2 days prior to entry and up to one week after leaving therefore you will need nine tablets plus the number the number of days holiday.
SKU: Atovaquone and Proguanil 250mg/100mg Categories: ,

Product Description

Atovaquone and Proguanil 250mg/100mg

Atovaquone and Proguanil 250mg/100mg to treat malaria, a disease caused by parasites which typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

For more information about Malaria, click here.

How to Take Atovaquone and Proguanil Tablets 250mg/100mg

When taking this medicine, drink it with food or with a dairy product at approximately the same time every day.

Before you go to a known malaria carrying area, it is advisable to take the medication 1 to 2 days prior to entry and up to one week after leaving.

Compared to other anti-malaria medication, the side effects of this drug aren’t as severe.

See our other anti-malaria products, here.

What you need to know before you take Atovaquone/Proguanil 250mg/100mg

Do not take Atovaquone/Proguanil if you are allergic to atovaquone, proguanil hydrochloride or any of the other ingredients of this medicine or if you have severe kidney disease.

Other medicines and Atovaquone/Proguanil Hydrochloride

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. Some medicines can affect the way Atovaquone/Proguanil Hydrochloride works, or Atovaquone/Proguanil Hydrochloride itself can strengthen or weaken the effectiveness of other medicines taken at the same time. These include:

  • metoclopramide, used to treat nausea and vomiting
  • the antibiotics, tetracycline, rifampicin and rifabutin
  •  efavirenz or certain highly active protease-inhibitors used to treat HIV
  • warfarin and other medicines that stop blood clotting
  •  etoposide used to treat cancer

Malaria is a serious tropical disease spread by mosquitoes. If it isn’t diagnosed and treated promptly, it can be fatal.

A single mosquito bite is all it takes for someone to become infected.

Symptoms of malaria
It’s important to be aware of the symptoms of malaria if you’re travelling to areas where there’s a high risk of the disease. Symptoms include:

a high temperature (fever)
sweats and chills
muscle pains
Symptoms usually appear between 7 and 18 days after becoming infected, but in some cases the symptoms may not appear for up to a year, or occasionally even longer.

When to seek medical attention
Seek medical help immediately if you develop symptoms of malaria during or after a visit to an area where the disease is found.

Malaria risk areas
Malaria is found in more than 100 countries, mainly in tropical regions of the world, including:

large areas of Africa and Asia
Central and South America
Haiti and the Dominican Republic
parts of the Middle East
some Pacific islands

The Fit for Travel website has more information about the risk of malaria in specific countries.

Preventing malaria
Many cases of malaria can be avoided. An easy way to remember is the ABCD approach to prevention:

awareness of risk – find out whether you’re at risk of getting malaria before travelling
bite prevention – avoid mosquito bites by using insect repellent, covering your arms and legs, and using an insecticide-treated mosquito net
check whether you need to take malaria prevention tablets – if you do,make sure you take the right antimalarial tablets at the right dose, and finish the course
diagnosis – seek immediate medical advice if you develop malaria symptoms, as long as up to a year after you return from travelling

Side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, but their exact
frequency is unknown.
Severe allergic reactions – signs include:
 rash and itching
 sudden wheezing, tightness of the chest or throat, or difficulty breathing or low blood pressure
 swollen eyelids, face, lips, tongue or other part of the body
Contact a doctor immediately if you get any of these symptoms and stop taking Atovaquone/Proguanil
Severe skin reactions:
 skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area
with a dark ring around the edge) (erythema multiforme)
 severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose,
eyes and genitals (Stevens-Johnson syndrome)
If you notice any of these symptoms contact a doctor urgently.
Most of the other side effects reported have been mild and have not lasted very long.
Very common side effects (may affect more than 1 in 10 people):
 headache
 feeling sick and being sick (nausea and vomiting)
 stomach pain
 diarrhoea
Common side effects (may affect up to 1 in 10 people):
 dizziness
 sleeping problems (insomnia)
 strange dreams
 depression
 loss of appetite
 fever
 rash, which may be itchy
 cough
Common side effects which may show up in your blood tests are:
 reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness of
 reduced numbers of white blood cells (neutropenia) which may make you more likely to catch
 low levels of sodium in the blood (hyponatraemia)
 an increase in liver enzymes
Uncommon side effects (may affect up to 1 in 100 people)
 anxiety
 an unusual awareness of abnormal beating of the heart (palpitations)
 swelling and redness of the mouth
 hair loss
Uncommon side effects that may show up in your blood tests:
 An increase in amylase (an enzyme produced in the pancreas)
Rare side effects (may affect up to 1 in 1,000 people):
 seeing or hearing things that are not there (hallucinations)
Not known (frequency cannot be estimated from the available data)
Other side effects have occurred in a small number of people but their exact frequency is unknown.
 inflammation of the liver (hepatitis)
 blockage of the bile ducts (cholestasis)
 increase in heart rate (tachycardia)
 inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots on the
skin but can affect other parts of the body
 fits (seizures)
 panic attacks, crying
 nightmares
 severe mental condition in which the person loses contact with reality and is unable to think and judge
 mouth ulcers
 blisters
 peeling skin
 increased sensitivity of the skin to sunlight
Other side effects that may show up in your blood tests:
 in people with severe kidney disease, decrease in all types of blood cells (pancytopenia)

Patient Information