• continuous combined Hormone Replacement Therapy
  • contains Estradiol and norethisterone acetate
  • effective relief from menopause symptoms
  • Buy With Confidence From UK Registered Pharmacy
  • Includes Free Prescription

Kliovance® is a continuous combined Hormone Replacement Therapy (HRT). It contains two types of
female hormones, an oestrogen and a progestagen providing effective relief from menopause symptoms that seriously hinder your daily life.

Kliovance® is used in postmenopausal women with at least 1 year since their last natural period.


Product Description

What is Kliovance?

Kliovance is a continuous combined Hormone Replacement Therapy (HRT). These HRT tablets are prescribed for women whose menopause symptoms are so bad that they affect their quality of life.It contains two types of female hormones, an oestrogen and a progestagen.

Kliovance® is used in postmenopausal women with at least 1 year since their last natural period.

Kliovance® is used for:
Relief of symptoms occurring after menopause
During the menopause, the amount of oestrogen produced by a woman’s body drops. This can cause
symptoms such as hot face, neck and chest (‘hot flushes’). Kliovance® alleviates these symptoms after
menopause. You will only be prescribed Kliovance® if your symptoms seriously hinder your daily life.

Prevention of osteoporosis
After the menopause some women may develop fragile bones (osteoporosis). You should discuss all
available options with your doctor.
If you are at an increased risk of fractures due to osteoporosis and other medicines are not suitable for you,
you can use Kliovance® to prevent osteoporosis after menopause.
Kliovance® is prescribed for women who have not had their womb removed, and whose periods stopped
more than a year ago.
There is only limited experience of treating women older than 65 years with Kliovance®

What you need to know before you take Kliovance®

Medical history and regular check-ups
The use of HRT carries risks which need to be considered when deciding whether to start taking it, or
whether to carry on taking it.

Once you have started on Kliovance® you should see your doctor for regular check-ups (at least once a
year). At these check-ups, discuss with your doctor the benefits and risks of continuing with Kliovance®.
Go for regular breast screening, as recommended by your doctor.

How does Kliovance work?

The menopause is a natural part of ageing that usually occurs between 45 and 55 years of age.
The levels of oestrogen and progesterone produced by the female body decrease and fluctuate as a woman ages.
This change in hormone levels cause the menopause and its symptoms the symptoms such as hot flushes and mood swings. Generally these symptoms are mild and HRT is only prescribed if the symptoms seriously hinder your daily life. Kliovance® is a continuous combined Hormone Replacement Therapy containing two types of
female hormones, an oestrogen and a progestagen. These help correct the balance and reduce the symptoms of menopause.

How do you take Kliovance?

Always take this medicine exactly as your doctor has told you.

Take one tablet once a day, at about the same time each day. Once you have finished all the 28 tablets in
the pack, start a new pack continuing the treatment without interruption.
For further information on the use of the calendar pack, see ‘User Instructions’ at the end of the package
You may start treatment with Kliovance® on any convenient day. However, if you are switching from an
HRT product when you have monthly bleeding, start your treatment straight after the bleeding has ended.

Your doctor should aim to prescribe the lowest dose to treat your symptom for as short as necessary. Speak to
your doctor if you think this dose is too strong or not strong enough.


The menopause is when a woman stops having periods and is no longer able to get pregnant naturally.

Periods usually start to become less frequent over a few months or years before they stop altogether.
The menopause is a natural part of ageing that usually occurs between 45 and 55 years of age, as a woman’s oestrogen levels decline. In the UK, the average age for a woman to reach the menopause is 51.

Symptoms of the menopause

Most women will experience menopausal symptoms. Some of these can be quite severe and have a significant impact on your everyday activities.

Common symptoms include:

hot flushes
night sweats
vaginal dryness and discomfort during sex
difficulty sleeping
low mood or anxiety
reduced sex drive (libido)
problems with memory and concentration

When to see a GP

It’s worth talking to a GP if you have menopausal symptoms that are troubling you or if you’re experiencing symptoms of the menopause before 45 years of age.

Treatments for menopausal symptoms

Your GP can offer treatments and suggest lifestyle changes if you have severe menopausal symptoms that interfere with your day-to-day life.

These include:

hormone replacement therapy (HRT) – tablets, skin patches, gels and implants that relieve menopausal symptoms by replacing oestrogen
vaginal oestrogen creams, lubricants or moisturisers for vaginal dryness
cognitive behavioural therapy (CBT) – a type of talking therapy that can help with low mood and anxiety
eating a healthy, balanced diet and exercising regularly – maintaining a healthy weight and staying fit and strong can improve some menopausal symptoms
Your GP may refer you to a menopause specialist if your symptoms do not improve after trying treatment or if you’re unable to take HRT.

What causes the menopause?

The menopause is caused by a change in the balance of the body’s sex hormones, which occurs as you get older.

It happens when your ovaries stop producing as much of the hormone oestrogen and no longer release an egg each month.


Most women will experience some symptoms around the menopause. The duration and severity of these symptoms varies from woman to woman.

On average, most symptoms last around 4 years from your last period. However, around 1 in every 10 women experience them for up to 12 years.

Changes to your periods
The first sign of the menopause is usually a change in the normal pattern of your periods. Eventually, you’ll stop having periods altogether.

Common menopausal symptoms

These can have a significant impact on daily life for some women.

Common symptoms include:

hot flushes – short, sudden feelings of heat, usually in the face, neck and chest, which can make your skin red and sweaty
night sweats – hot flushes that occur at night
difficulty sleeping – this may make you feel tired and irritable during the day
a reduced sex drive (libido)
problems with memory and concentration
vaginal dryness and pain, itching or discomfort during sex
mood changes, such as low mood or anxiety
palpitations – heartbeats that suddenly become more noticeable
joint stiffness, aches and pains
reduced muscle mass
recurrent urinary tract infections (UTIs)
The menopause can also increase your risk of developing certain other problems, such as weak bones (osteoporosis).

See your GP if you’re finding your symptoms particularly troublesome, as treatments are available. Read about how to manage symptoms of the menopause.


The main treatment for menopausal symptoms is hormone replacement therapy (HRT), although other treatments are also available for some of the symptoms.

Hormone replacement therapy (HRT)

HRT involves taking oestrogen to replace the decline in your body’s own levels around the time of the menopause. This can relieve many of the associated symptoms.

There are two main types of HRT:

combined HRT (oestrogen and progestogen) – for women with menopausal symptoms who still have their womb (oestrogen taken on its own can otherwise increase your risk of womb cancer)
oestrogen-only HRT – for women who have had their womb removed in a hysterectomy
HRT is available as tablets, skin patches, a gel to rub into the skin or implants.

HRT is extremely effective at relieving menopausal symptoms, especially hot flushes and night sweats, but there are a number of side effects, including breast tenderness, headaches and vaginal bleeding. It’s also associated with an increased risk of blood clots and breast cancer in some women.

HRT is not advisable for some women, such as those who have had certain types of breast cancer or are at high risk of getting breast cancer.

Your GP can give you more information about the risks and benefits of HRT to help you decide whether or not you want to take it.

Hot flushes and night sweats

If you experience hot flushes and night sweats as a result of the menopause, simple measures may sometimes help, such as:

wearing light clothing
keeping your bedroom cool at night
taking a cool shower, using a fan or having a cold drink
trying to reduce your stress levels
avoiding potential triggers, such as spicy food, caffeine, smoking and alcohol
taking regular exercise and losing weight if you’re overweight
If the flushes and sweats are frequent or severe, your GP may suggest taking HRT.

Mood changes

Some women experience mood swings, low mood and anxiety around the time of the menopause.
Self-help measures such as getting plenty of rest, taking regular exercise and doing relaxing activities such as yoga and tai chi may help. Medication and other treatments are also available, including HRT and cognitive behavioural therapy (CBT). Antidepressants may help if you’ve been diagnosed with depression.

Reduced sexual desire

It’s common for women to lose interest in sex around the time of the menopause, but HRT can often help with this.

Vaginal dryness and discomfort

If your vagina becomes dry, painful or itchy as a result of the menopause, your GP can prescribe oestrogen treatment that’s put directly into your vagina as a pessary, cream or vaginal ring.

This can safely be used alongside HRT.

You’ll usually need to use vaginal oestrogen indefinitely, as your symptoms are likely to return when treatment stops. However, side effects are very rare.

You can also use over-the-counter vaginal moisturisers or lubricants in addition to, or instead of, vaginal oestrogen.

Weak bones

Women who have been through the menopause are at an increased risk of developing osteoporosis (weak bones) as a result of the lower level of oestrogen in the body.

You can reduce your chances of developing osteoporosis by:

taking HRT – HRT can help to prevent osteoporosis, although this effect doesn’t tend to last after treatment stops
exercising regularly – including weight-bearing and resistance exercises
eating a healthy diet that includes plenty of fruit, vegetables and sources of calcium, such as low-fat milk and yoghurt
getting some sunlight – sunlight on your skin triggers the production of vitamin D, which can help to keep your bones strong
stopping smoking and cutting down on alcohol
taking calcium and/or vitamin D supplements if you don’t feel you’re getting enough of these – discuss this with your GP

Follow-up appointments

If you’re having treatment for your menopausal symptoms, you’ll need to return to your GP for a follow-up review after 3 months, and once a year after that.

Side Effects

Like any other medication, Kliovance can cause side effects. Not everyone will experience side effects, however, and they usually only last for the first few months of taking HRT. If you have any concerns about possible side effects, you should see your doctor.

The following conditions occur more frequently in women who are taking HRT than those who aren’t:

– breast cancer
– ovarian cancer
– endometrial hyperplasia / cancer (abnormal growth / cancer of the womb lining)
– blood clots in the veins of the legs or lungs (venous thromboembolism)
– heart disease
– stroke
– memory loss if HRT is started over the age of 65

Three of the most common side effects of Kliovance are:

– Breast pain or tenderness
– Vaginal bleeding
– Headaches
– You may experience some irregular bleeding or spotting in the first 3-6 months of taking Kliovance. This is due to your body adjusting to the medication. If the bleeding continues after 6 months, you should see your doctor.

Taking HRT in the form of tablets (rather than as a patch or gel, for example) can cause an increased risk of developing a blood clot. Your doctor will discuss all the risks with you, but it’s important that you fully understand the risks associated with HRT before you start a course of treatment.

For a full list of Kliovance side effects, please see the patient information leaflet.

Further Information